FoundMyFitness
by Rhonda Patrick, Ph.D.A podcast about health, science, nutrition, aging, and fitness.
Copyright: ℗ & © 2022 FoundMyFitness
Episodes
#049 Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More
1h 22m · PublishedDavid A. Sinclair
David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor.
Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer.
In this episode, you'll discover:
- 00:00:00 - Introduction
- 00:17:59 - Caloric restriction, fasting, and exercise activate sirtuin longevity genes
- 00:21:47 - Boosting NAD+ levels reduces sirtuin loss with age
- 00:23:03 - Resveratrol extends sirtuin activation
- 00:27:36 - NAD+ resets epigenetic aging clocks
- 00:31:54 - Yamanaka factors reprogram adult cells into stem cells
- 00:46:48 - Resveratrol is a xenohormetic compound
- 00:55:35 - Resveratrol improved cognitive function in Alzheimer's disease
- 00:58:03 - NR and NMN improve cognitive function
- 01:06:19 - NMN delays aging in multiple organs
- 01:01:22 - Challenges of translating animal research
If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/david-sinclair
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#048 Sauna Use as an Exercise Mimetic for Heart and Healthspan
46m · PublishedThis podcast is the audio from a presentation Dr. Rhonda Patrick gave on how the sauna may be an exercise mimetic for heat health and healthspan. Sauna use has emerged as a means to increase lifespan and improve overall health, based on compelling data from observational, interventional, and mechanistic studies. Listen in to find out more.
In this episode, you'll discover:
- 00:00:00 - Introduction
- 00:03:01 - Clinical research shows that sauna improves cardiovascular health
- 00:09:19 - Finnish sauna vs Waon infrared therapy
- 00:12:35 - The mechanisms of sauna use mimic exercise
- 00:15:58 - Heat shock proteins mediate the benefits of sauna use
- 00:23:42 - Sauna use reduces inflammation
- 00:25:54 - Sauna use is enjoyable and safe
- 00:28:55 - Crowd questions and answers
If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/sauna-heart-presentation
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#047 Exercise as a Treatment for Depression
17m · PublishedIn this short episode, Dr. Patrick discusses some of the compelling science including observational studies, randomized controlled trials, and human mechanistic studies that suggests exercise is a powerful tool for preventing or managing the symptoms of depression and mental illness. Moreover, she talks about the specific types of exercise and exercise parameters that evidence suggests might be the most helpful for depression.
This podcast started its life as a video, so make sure to check out the full video or the references and episode notes on the episode page.
In this episode, you'll discover:
- 00:00:00 - Introduction
- 00:01:51 - Multiple types of research support the anti-depressant effects of exercise
- 00:04:45 - Exercise boosts serotonin and blocks harmful kynurenine
- 00:10:00 - Exercise causes beneficial inflammation that boosts BDNF
- 00:13:18 - Depression lowers BDNF and neuroplasticity
- 00:15:08 - Exercise increases endocannabinoids and endorphins
- 00:16:09 - Concluding thoughts
If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/exercise-depression
Join over 300,000 people and get the latest distilled information on depression straight to your inbox weekly: https://www.foundmyfitness.com/newsletter
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#046 Dr. Elissa Epel on Telomeres and the Role of Stress Biology in Cellular Aging
1h 13m · PublishedElissa Epel
Elissa Epel, PhD, is a Professor in the Department of Psychiatry at the University of California, San Francisco where she serves as the director of the Aging, Metabolism, and Emotions Center.
Her research centers on the mechanisms of healthy aging and the associations between stress, telomere length, addiction, eating, and metabolic health.
In this episode, we dive deep into the world of telomeres, the length of which is one of the useful biomarkers scientists have for getting a sense of the differences between how individuals or groups of individuals age. Telomere shortening is both a cause and a symptom of aging and plays key roles in not only how long we live, but in how well. Lifestyle factors such as poor nutrition and smoking can accelerate telomere shortening by generating oxidative stress and inflammation.
In this episode, we discuss:
- 00:00 - Introduction and overview
- 12:14 - What are telomeres
- 17:23 - Telomerase activity and cancer
- 22:22 - Factors affecting telomere length:
- 24:50 - Diet, coffee, and sugar
- 30:16 - Chronic stress
- 35:01 - Exercise
- 40:14 - Pregnancy and pre-conception
- 51:19 - Omega-3s EPA and DHA
- 52:12 - Vitamin D
- 54:01 - Weight loss and glucose management
- 01:00:30 - Meditation
- 01:07:39 - Consumer telomere length tests
If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/elissa-epel
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#045 Dr. Matthew Walker on Sleep for Enhancing Learning, Creativity, Immunity, and Glymphatic System
2h 47m · PublishedMatthew Walker
Matthew Walker, Ph.D., is a professor of neuroscience and psychology at the University of California, Berkeley, and serves as the Director of the Center for Human Sleep Science.
Walker's research examines the impact of sleep on human health and disease. One area of interest focuses on identifying "vulnerability windows" during a person's life that make them more susceptible to amyloid-beta deposition from loss of slow wave sleep and, subsequently, Alzheimer's disease later in life.
Dr. Walker earned his undergraduate degree in neuroscience from the University of Nottingham, UK, and his Ph.D. in neurophysiology from the Medical Research Council, London, UK. He is the author of the New York Times best-selling book Why We Sleep: Unlocking the Power of Sleep and Dreams.
In this episode, we discuss:
- 00:00 - Introduction
- 08:47 - Sleep boosts learning
- 21:21 - Manipulating sleep to enhance learning
- 26:28 - REM sleep, dreams, and memory encoding
- 34:46 - Sleep deprivation causes loneliness
- 46:36 - Sleep is disturbed in all neuropsychiatric conditions
- 52:30 - Bright light exposure
- 01:00:02 - How much sleep is enough?
- 01:10:21 - Inflammation triggers sleep
- 01:26:16 - Bidirectional relationship between poor sleep and Alzheimer's disease
- 01:35:12 - Deep sleep deprivation increases beta-amyloid
- 01:41:40 - Preventing dementia
- 01:48:44 - Sleep tracking technology
- 01:56:25 - Four Pillars of Sleep
- 02:06:02 - Metabolism and microbiome
- 02:23:34 - Tips for better sleep
If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/matthew-walker
Join over 300,000 people and get the latest distilled information on sleep for enhanced learning straight to your inbox weekly: https://www.foundmyfitness.com/newsletter
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#044 Fasting Q&A with Dr. Rhonda Patrick and Mike Maser
49m · PublishedThis episode features a Q&A session with Dr. Rhonda Patrick. The questions were sourced from social media followers of both FoundMyFitness and also Zero Fasting Tracker, a convenient mobile app used widely in the fasting community for logging.
In this 45-minute podcast, Dr. Patrick answers some of the most popular questions related to fasting, including:
- 00:03:46 - What effects do coffee, supplements, and amino acids have on fasting?
- 00:12:29 - Should you consume electrolytes on a fast?
- 00:14:50 - What evidence is there that one method of fasting is more beneficial than others?
- 00:24:01 - What effect does the consumption of exogenous ketones have on fasting?
- 00:29:30 - Are there downsides to exercise during fasting?
- 00:34:31 - What role does fasting play in the growth-longevity tradeoff?
- 00:49:48 - What's the ideal way to break a fast?
If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/zero-fasting-qa
Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter
Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
#043 Dr. Dale Bredesen on Preventing and Reversing Alzheimer's Disease
1h 14m · PublishedDale E. Bredesen
Dale E. Bredesen, M.D., is a professor of neurology at the Easton Laboratories for Neurodegenerative Disease Research at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA).
Dr. Bredesen's laboratory focuses on identifying and understanding basic mechanisms underlying the neurodegenerative process and the translation of this knowledge into effective treatments for Alzheimer's disease and other neurodegenerative conditions. He has collaborated on the publication of more than 220 academic research papers.
In this episode, we discuss:
- 00:00 - Introduction
- 06:00 - What is Alzheimer's disease?
- 09:29 - Alzheimer's types - hot, dry, and toxic
- 18:56 - APOE-4 gene triples risk of Alzheimer's disease
- 20:55 - Cognoscopy for dementia detection
- 23:11 - Lifestyle interventions
- 32:33 - Keto flex 12/3 diet can treat dementia
- 50:58 - Omega-3s resolve inflammation
- 57:39 - Sauna use detoxifies the body
- 01:06:05 - Available consumer tests
If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/dale-bredesen
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#042 Dr. Valter Longo on Resetting Autoimmunity and Rejuvenating Systems with Prolonged Fasting & the FMD
1h 17m · PublishedDr. Valter Longo
Dr. Longo is the current director of the longevity institute at the University of Southern California and also director of the Oncology and Longevity Program at the Institute of Molecular Oncology Foundation in Milan, Italy.
Dr. Longo’s research focuses understanding the biological mechanisms that regulate the aging process, the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human diseases.
In this episode, we discuss...
- 00:00 - Introduction
- 09:30 - Defining fasting
- 16:10 - Insulin/growth hormone axis and aging
- 21:37 - Growth hormone deficiency protects from some diseases
- 30:55 - Fasting vs a ketogenic diet for cancer
- 40:13 - The fasting-mimicking diet (FMD)
- 48:28 - "Yo-yo" fasting once per month
- 52:21 - Fasting does not reduce muscle mass
- 57:03 - Autophagy and apoptosis are our repair mechanisms
- 01:02:33 - Refeeding is necessary to rebuild healthy cells
- 01:05:31 - Top 5 biomarkers of healthy aging
If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/valter-longo-2
Join over 300,000 people and get the latest distilled information straight to your inbox weekly: https://www.foundmyfitness.com/newsletter
Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
#041 Dr. Charles Raison on Depression, the Immune-Brain Interface & Whole-Body Hyperthermia
1h 58m · PublishedCharles Raison
Charles Raison, M.D. is a professor at the School of Human Ecology at the University of Wisconsin-Madison and Founding Director of the Center for Compassion Studies in the College of Social and Behavioral Sciences at the University of Arizona.
Dr. Raison’s research focuses on inflammation and the development of depression in response to illness and stress. He also examines the physical and behavioral effects of compassion training on the brain, inflammatory processes, and behavior as well as the effect of heat stress as a potentially therapeutic intervention major depressive disorder.
In this episode, you'll discover:
- 00:00 - Introduction
- 06:26 - Role of inflammation in depression
- 10:08 - Evolutionary mechanism
- 16:19 - Genetics of depression
- 22:57 - How obesity causes depression biochemically
- 33:32 - Does exercise treat depression
- 36:08 - Hyperthermia as treatment
- 46:08 - Inflammation promotes depression
- 53:39 - Did we evolve to need hormetic stress?
- 01:03:38 - Heat-shock proteins
- 01:06:10 - Repurposing ancient wisdom
- 01:17:31 - Psychedelics and meditation
- 01:27:51 - What is the role of conventional pharmacotherapy?
- 01:35:19 - Lifestyle modifications for depression
- 01:42:21 - Why light and circadian rhythm are important for mental health
If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/charles-raison
Join over 300,000 people and get the latest distilled information on depression straight to your inbox weekly: https://www.foundmyfitness.com/newsletter
Become a FoundMyFitness premium member to get access to exclusive episodes, emails, live Q+A’s with Rhonda and more: https://www.foundmyfitness.com/crowdsponsor
#040 Dr. Eric Verdin on Ketogenic Diet Longevity, Beta-Hydroxybutyrate & HDAC Inhibitors
1h 3m · PublishedEric M. Verdin
Eric M. Verdin, M.D. is the fifth president and chief executive officer of the Buck Institute for Research on Aging and is a professor of Medicine at UCSF.
Dr. Verdin's laboratory focuses on the role of epigenetic regulators in the aging process, the role of metabolism and diet in aging and on the chronic diseases of aging, including Alzheimer’s, proteins that play a central role in linking caloric restriction to increased healthspan, and more recently a topic near and dear to many of you, ketogenesis. He's held faculty positions at the University of Brussels, the NIH and the Picower Institute for Medical Research.
In this episode, you'll discover:
- 00:00 - Introduction
- 07:32 - Interventions to prolong lifespan
- 10:42 - The role of insulin pathways in aging
- 16:25 - HDAC inhibition by ketones
- 27:52 - Protein activates mTOR & IGF-1
- 30:28 - PPAR-alpha activation facilitates benefits of a ketogenic diet
- 35:28 - What biomarkers can predict aging?
- 39:38 - Cellular NAD+ levels decrease with age
- 52:47 - Ketogenic diet safety
- 56:07 - Intermittent fasting as an alternative to a keto diet
If you’re interested in learning more, you can read the full show notes here: https://www.foundmyfitness.com/episodes/69
Join over 300,000 people and get the latest distilled information on ketogenic diet & longevity straight to your inbox weekly: https://www.foundmyfitness.com/newsletter
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FoundMyFitness has 89 episodes in total of non- explicit content. Total playtime is 111:05:36. The language of the podcast is English. This podcast has been added on November 27th 2022. It might contain more episodes than the ones shown here. It was last updated on May 12th, 2024 10:41.