Big Brains

The United States is facing a real mental health crisis. In the last few years, one possible treatment has gotten a lot of press: psychedelic drugs. But what is actually happening in a person’s brain when they take a psychedelic? Could understanding the biology and the chemistry allow us to make better and safer versions of these drugs—and maybe even create psychedelics without the hallucinations?

In this episode, we speak with Assoc. Prof. David E. Olson, founding director of the UC Davis Institute of Psychedelics and Neurotherapeutics. Olson and his lab have been researching the therapeutic effects of psychedelic drugs and how they could be used to treat neuropsychiatric diseases, including depression, anxiety disorders and even addiction. His lab’s is researching how to develop non-hallucinogenic psychedelics, also called next-generation neurotherapeutics.

The Big Brains team is taking some time off during the holidays but for all those travelers out there heading home, we wanted to make sure you still had your favorite podcast in your feed. So, we’re resharing one of our most popular episodes ever. It’s about the science of happiness.

What is the key to living a happy and fulfilling life? The answer is actually quite simple, according to the two scholars behind the longest scientific study of happiness every conducted.

Beginning in 1938, the Harvard Study of Adult Development tracked three generations of families to uncover what contributed to their happiness. In their new book, The Good Life: Lessons from the World's Longest Scientific Study of Happiness, Robert Waldinger and Marc Schulz tell the stories behind their participants' lives and provide key insights on the recipe to happiness.

Marc Schulz, a professor at Bryn Mawr College, joins the podcast to discuss the book and their study.

Here’s the question you’re going to be asking for the next 30 minutes: Did I freely choose to listen to this podcast, or did I actually have no choice at all? Most of us probably believe we have free will. We feel like we make decisions, and that each of us is responsible for the consequences of our actions. But what if that’s all just an illusion?

Robert Sapolsky is a renowned professor of biology and neurology at Stanford University, but he’s also the author of best-selling scientific books such as “Behave”. He’s always been focused on the biological mechanisms that shape our actions, but in his latest book, “Determined: A Science of Life Without Free Will” he’s going a step further: He says the science shows that our biology doesn’t just shape our actions, but completely controls them. In this episode, he argues that letting go of the illusion of free will could radically reshape our world.

Climate change can feel like an impossible crisis these days. Every week there is some new report about the irreversible damage we’re doing to our planet and the havoc it will bring to people’s lives. We all knowcutting emissions is the solution, yet governments and companies seem no closer to meeting the goalsthatscientistssay we must hit. It can feel hopeless.

There is onepossiblecontroversial solutionto climate change many in the mainstream haven’t discussed. It’s so controversial,in fact,that some experts say we shouldn’t even be discussing it. But University of Chicago Professor DavidKeithsays we need to talk about it. It’s calledsolar geoengineering—the process in which you reflect a small fraction of sunlight back into space. As the founding director of the Climate SystemsEngineeringInitiativeat UChicago,Keithis leading a team that will researchsolargeoengineeringand other novel solutions to climate change.

By now, you've probably heard about the dangers of PFAS “forever chemicals.” These chemicals are all around us—they're in waterproof hiking boots, electronics, nonstick pans and even our drinking water—but there's no way for them to break down in our environment. Epidemiological studies have linked to these chemicals to numerous diseases—from kidney cancer, liver cancer, obesity, decreased fertility and more.

American toxicologist LindaBirnbaumhas been sounding the alarms about how PFAS are harming our health for the last few decades. She was previously the director of theNational Institute for Environmental Health Sciences at the NIH and is currently anadjunct professor at the University of North Carolina, Chapel Hill. She explains that while we cannot completely avoid PFAS, there are steps we can take to limit our exposure.

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How many times have you heard this phrase: “Back in the day, people were nicer” or “People aren’t as kind as they used to be?” Most of us have experienced the feeling that people are becoming meaner over time, year after year. But is it true? Are people really less kind than they used to be?

That’s the question that has bothered psychologist Adam Mastroianni most of his life. He set out to find an answer—a search that recently culminated in a paper published in the journal Nature titled, “The Illusion of Moral Decline.” While the title may be a giveaway for his findings, he asks: If people are becoming less moral, why do we all feel the same way—and what can we do to shake this “illusion?”

Link to the advertised Chicago Booth Review Podcast:https://www.chicagobooth.edu/review/podcast?source=cbr-sn-bbr-camp:podcast23-20231102#sort=%40articledate%20descending

Of the academic books that have become household names, “Freakonomics” must be at the top of the list. The 2005 book by University of Chicago scholar Steven Levitt and journalist Stephen Dubner created not only a whole new way of thinking about discovering answers to complex problems, but launched a media empire—from book sequel to a movie to a hit podcast.

On this special episode, we sat down with Levitt during the inaugural UCPN Podcast Festival, to talk about the legacy of Freakonomics. Almost 20 years later, he told our audience how he views himself as a “data scientist” and not just an economist, what he’s learned about using a coin flip to make hard decisions in life, and why he thinks he may have found the “holy grail” of solving crime.

Since the Jan. 6, 2021 attack on the U.S. Capitol, University of Chicago Prof. Robert Pape has been closely observing the threats to our democracy. Now, the renowned terrorism expertsays that violent ideas coming from a dedicated minority are moving from fringe to mainstream.

In 2021, Pape's team along with NORC at the University of Chicago launched the Dangers to Democracy tracker, an ongoing series of surveys to track Americans' thoughts and attitudes about political violence.In one recent survey, about 12 million Americans said they believe violence is justified to restore Trump to power. Still, Pape believes the data may give us some answers about how to move forward, and how to strengthen the center.

Free speech is probably one of the most polarizing public topics of debate. And those arguments only become more intense when it comes to free expression on college and university campuses. Should professors be allowed to say whatever they want? What about speakers being invited to campus? Who gets to say what is acceptable and unacceptable?

The University of Chicago has had a unique and long history of defending free expression, and this year is building upon that commitment by launching The Chicago Forum on Free Inquiry and Expression. That forum is being led by renowned UChicago law professor Tom Ginsburg. He joins our podcast along with President Paul Alivisatos to talk about why universities must have a commitment to free inquiry—and how this new forum plans to promotefree and open discourse, while addressing present-day challenges.

Can you heal faster just by tricking your brain? Could you lose weight with only a change of mindset? Could you think yourself into being younger? If you think the answer to all these questions is no, you haven’t read the research from renowned Harvard University psychologist Ellen Langer.

Langer is a bit of a legend. She’s the first woman to ever receive tenure in psychology at Harvard, and her work has earned her the moniker: “The Mother of Mindfulness”. Her 40-year research career into the mind-body connection—and how mindfulness can hack that system—has delivered some unbelievable results that she believes hold the key to revolutionizing our health.She complies all of her work in her latest book “The Mindful Body: Thinking Our Way to Chronic Health.”