130 Got a Mysterious Chronic Condition? It Might be Mast Cell Activation Syndrome
50m
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Thyroid Mystery Solved: Hashimoto's and Hypothyroidism Revealed
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The Case:
- Julie has digestive issues, headaches, lots of skin rashes and irritation, brain fog, and fatigue
- She is also very sensitive to environmental triggers like fragrances, smoke, and chemicals.
- She eats and lives as clean as possible but nothing seems to help.
- She’s seen a dozen doctors who have prescribed a variety of medications but nothing helped.
It’s so common for conventional doctors to focus on treating the symptoms as if they are unrelated instead of considering what the collection of symptoms might mean. Julie knew that her symptoms had to be connected which is when she reached out to me. My feeling was that this was a systemic issue and we got to work investigating the root cause of her problems.
The Investigation
With my suspicions of a systemic issue, I knew that Beth O’Hara would be a great source of information. She’s been on Health Mysteries Solved before to speak about Oxalates (episode 67) and Histamines (episode 81). This time, I wanted to dive into the topic of Mast Cells and Mast Cell Activation Syndrome which is Beth’s expertise.
What are Mast Cells?
Mast cells are one of the most important types of immune cells in our bodies. They're present at every interface between our bodies and the outside world, and they're also found in every single tissue except for the retina. So, if we think about that, they're in the skin, in the lining of the sinus passages, in the digestive tract from the mouth to the stomach, and they're also found in muscles and bones. They migrate to very important areas like nerve endings and the brain's limbic system.
Mast cells are responsible for a number of functions ranging from the sleep-wake cycle to pregnancy and wound healing. They also help the body monitor for whether or not we're safe from things like toxins, mold, candida, pathogens, parasites, viruses and bacteria. They even monitor for co-infections (like lyme disease). Mast cells are also looking for all types of stressors including psychological stress, physical stress and stress caused by outside factors like electromagnetic fields (EMF) in the environment.
How do Mast Cells Work?
Mast cells use what are called receptors - you can think of them like little antennae on the outside of the cell. There are over 200 of these receptors sending out signals using mediators. There are over 1000 different mediators. All of these allow the cells to connect with and monitor the different functions of the body.
When a mast cell detects an issue it will respond, often causing inflammation. It is not the only immune response but it is one of the primary cells responsible for answering a threat to the immune system.
The problem is that our modern world has more threats to the immune system that can cause mast cells to react. These include things like mold, high levels of EMF (wifi, smart homes, etc add to these high levels), environmental chemicals and other toxins. The challenge is that the mast cells are constantly triggered (or in activation) by these things and they don’t have time to rest and reset. This can overwhelm the mast cells and create a chronic issue.
The Link Between Autoimmunity and Mast Cell Activation
Mast cells are heavily involved in the development of various autoimmune diseases. The mast cells are involved in both innate and adaptive immunity. Mast cells respond to the initial threat from a pathogen but when that fails, they shift their response and this can be what causes chronic inflammation. This continues as long as there are unresolved root triggers over an extended period of time. Over time, this opens the door for the development of autoimmunity in people who are predisposed for it.
So, if we want to avoid autoimmunity, we need to respond faster to the root trigger so that the mast cell response can be regulated. Regulating the mast cells can also reverse autoimmunity, in some cases, if you identify which mast cells have been activated.
Different mast cells can be triggered (and often triggered together to create a bigger issue). For example, the GI mast cells and the skin mast cells. After determining which mast cells have been activated, you need to understand which receptors are now hyper-sensitive and which mediators are involved.
Mast Cell Activation Syndrome Symptoms and Diagnosis
The complexity of what is happening is one of the reasons why it is so hard to diagnose MCAS. Beth says that the average diagnosis takes up to 10 years and the criteria for diagnosis is still being debated. She shared that a population study (pre-COVID) found that up to 17% of the population are dealing with MCAS. That’s hundreds of millions of people with MCAS, the majority of which are undiagnosed. Experts speculate that up to 75% of all chronic illness could involve MCAS.
While there is a long list of potential symptoms, Beth shared some of the most common. The symptoms of Mast Cell Activation Syndrome include:
- Pain in the muscles and joins
- Brain fog
- Fatigue
- GI issues like:
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- Diarrhea
- Constipation
- Bloating
- Pain (in the gut or stomach)
- Discomfort after eating
- Esophagus swelling
- Mouth burning
- Acid reflux
- Depression or anxiety
- Insomnia (especially falling asleep or waking up between 2-4 am)
- Skin issues including:
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- Rashes
- Hives
- Psoriasis
- Eczema
- Bladder Interstitial Cystitis (urinary pain and burning)
- Hormonal issue (hormonal imbalances)
- Breathing issues including:
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- Shortness of breath
- Excess sinus mucus production (postnasal drip)
- Hypersensitivity (often to fragrances)
To assess your symptoms, Beth has a free Symptoms Survey you can take here. There are some lab tests that will also help to diagnose MCAS but these tests are limited so it’s important to also consider the symptoms.
The episode 130 Got a Mysterious Chronic Condition? It Might be Mast Cell Activation Syndrome from the podcast Thyroid Mystery Solved: Hashimoto's and Hypothyroidism Revealed has a duration of
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As soon as you find out that you have a thyroid issue, or that you’re diagnosed with Hashimoto's, your instinct is to learn as much as you can. As the internet becomes more and more crowded with information, it can be so difficult to find useful information. And, it can be hard to determine who to trust as you try to navigate your way to overcoming your Hashimoto’s and hyperthyroid symptoms.
I know because I was once in this position and because I’ve spent the last decade helping Hashimoto’s and hypothyroid patients regain their health.
A lot has changed in this time - and more changes are coming (more on that at the end of these show notes) but over the years, I’ve discovered that there are 5 key drivers of success when it comes to overcoming your thyroid issues and Hashimoto’s symptoms. I share them in this episode along with a big announcement about this show and support for anyone dealing with autoimmunity, Hashimoto’s, and hypothyroidism.
The 5 Keys to Overcoming Hashimoto’s
These five proven strategies have made a huge difference for me and many of my clients struggling with Hashimoto's.
1. Diet: Balancing Blood Sugar Is Key
It all starts with food! While everyone's needs are unique, there's one common thread: balanced blood sugar. Eating a balanced diet with all the macronutrients – carbs, proteins, and fats – is crucial. Avoid blood sugar spikes by avoiding excessive carbs at once and pair your meals with protein and healthy fats. Remember, stress can be physical too! Unbalanced blood sugar creates stress on the body, hindering progress.
2. Clean Eating: Ditching Chemicals and Going Organic
Our world is full of chemicals like pesticides and herbicides. Research shows these chemicals can negatively impact our health. So, the cleaner you eat, the better. Prioritize whole, unprocessed foods straight from the earth. Consider going organic, especially for the "Dirty Dozen" – the foods most heavily laden with pesticide residues (check the Environmental Working Group's list). Organic meats and dairy are also beneficial to avoid added hormones and antibiotics.
3. Identify and Address Food Sensitivities
Gluten is a common culprit for many with Hashimoto's. Not everyone needs to be gluten-free, but some may have the DQ2 and DQ8 genes, making gluten processing difficult. When you consume gluten, even without immediate symptoms, the immune system attacks it. This can lead to accidental attacks on the thyroid due to molecular similarities between gluten and thyroid molecules (cross-reactivity).
I personally struggled with gluten for years, but identifying it as a trigger made a significant difference. Consider exploring food sensitivities to see what might be hindering your progress.
4. Targeted Supplements for Personalized Support
Supplements can be extremely helpful, but a one-size-fits-all approach doesn't work. Our immune triggers and thyroid types vary. However, some supplements have been particularly beneficial for me and my clients:
- SPM (Specialized Proresolving Mediators): Helps reduce inflammation and calm the immune system.
- Glutathione: An amazing antioxidant that supports detoxification and promotes immune balance. I recommend the APEX Trizoma Glutathione brand for its liquid form and good taste.
- Vitamin D: Another immune balancer and natural anti-inflammatory. I recommend Designs for Health's Vitamin D Synergy or Vitamin D Supreme.
- Remember: These are just a few suggestions. It's important to find what works best for you.
5. Calm the Nervous System
The nervous system has a powerful influence on the immune system. A calmer nervous system translates to a more balanced immune system. Here are some ways to achieve this:
- Meditation
- Movement
- Visualization
- Reframing negative thoughts
- Releasing negativity
- Setting positive intentions
- Affirmations
- Faith
- Mantras
- Self-worth exercises (like clearing feelings of "not enoughness")
I find meditation and movement particularly helpful. Experiment and find what works for you.
Bonus Tip #1: Building a Morning Practice Can Make a Big Difference
Mornings can be tough, but incorporating a self-care routine can shift the entire day. I recommend starting your day a little earlier, even before the kids wake up (believe me, I get it, I'm not a morning person either!).
The book "The Miracle Morning" by Hal Elrod offers great tips on establishing a morning practice and provides ideas to optimize your early-start time. It’s hard to believe but the benefits of improved sleep quality and stress reduction outweigh the initial sacrifice of a little extra sleep.
Bonus Tip #2: Increase Your Capacity to Receive
This may sound surprising, but it's incredibly powerful. We all want optimal health, vibrant energy, and freedom from Hashimoto's. But sometimes, we struggle to allow ourselves to truly receive these things.
My question for you is, can you allow all of the things you picture when you see yourself in optimal health? Take a moment and really feel this question in your body. How much good health can you really receive without feeling like, ‘Oh, gosh, this is too much’? All the things that you want to be able to do when you are feeling better; when you have more energy; when you lose that weight – how much of that joy can you actually allow and take in?
This might feel like a strange concept, but explore it. Notice any tightness or resistance in your body when you imagine complete freedom from symptoms. Do you feel undeserving of such good health?
We often have subconscious beliefs about deservingness. We may feel good things like joy, love, and health need to be earned. This can block our ability to receive the very things we desire.
You’ve heard the stories about lottery winners who lose their winnings quickly. This is often due to a deep-seated feeling of not deserving it. They sabotage their own success.
The same can happen with health. If you don't feel deserving of good health, your nervous system won't feel safe receiving it. This can lead to unconscious sabotage of your healing journey.
Learning to receive is crucial for overcoming Hashimoto's and any chronic health issues. I have entire programs dedicated to overcoming these blocks: "Clear Your Thyroid Blocks" and my signature program "Thyroid Mystery Solved." You can find more information on my website … which brings me to my important announcement!
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