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115. The Future of Therapy Is Psychedelic

53m · People I (Mostly) Admire · 30 Sep 03:00

For 37 years, Rick Doblin has been pushing the F.D.A. to approve treating post-traumatic stress disorder with MDMA, better known as Ecstasy. He tells Steve why he persisted for so long, why he doesn’t like calling drug use “recreational,” and what he learned from his pet wolf.

RESOURCES:

  • "MDMA-Assisted Therapy for Moderate to Severe PTSD: A Randomized, Placebo-Controlled Phase 3 Trial," by Jennifer M. Mitchell, Marcela Ot’alora G., Bessel van der Kolk, Scott Shannon, Michael Bogenschutz, Rick Doblin, et al. (Nature Medicine, 2023).
  • "MDMA Therapy Inches Closer to Approval," by Rachel Nuwer (The New York Times, 2023).
  • "Psychedelics Reopen the Social Reward Learning Critical Period," by Romain Nardou, Edward Sawyer, Young Jun Song, Gül Dölen, et al. (Nature, 2023).
  • "The Social Costs of Keystone Species Collapse: Evidence from the Decline of Vultures in India," by Eyal Frank and Anant Sudarshan (SSRN, 2023).
  • "Global Health, Climate Change and Migration: The Need for Recognition of 'Climate Refugees,'" by Saverio Bellizzi, Christian Popescu, Catello M. Panu Napodano, Maura Fiamma, and Luca Cegolon (Journal of Global Health, 2023).
  • "Comparison of Prolonged Exposure vs Cognitive Processing Therapy for Treatment of Posttraumatic Stress Disorder Among U.S. Veterans," by Paula P. Schnurr, Kathleen M. Chard, Josef I. Ruzek, et al. (JAMA Network Open, 2022).
  • "MDMA-Assisted Therapy for Severe PTSD: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study," Jennifer M. Mitchell, Michael Bogenschutz, Alia Lilienstein, Charlotte Harrison, Rick Doblin, et al. (Nature Medicine, 2021).
  • "Inner City Blues: Children Raised in Inner-Cities Face Comparable PTSD Causing Conditions and Consequences as Military Veterans and Deserve Our Attention," by Eric Citizen (SSRN, 2019).
  • "Intergenerational Transmission of Trauma Effects: Putative Role of Epigenetic Mechanisms," by Rachel Yehuda and Amy Lehrner (World Psychiatry, 2018).
  • "Durability of Improvement in Post-Traumatic Stress Disorder Symptoms and Absence of Harmful Effects or Drug Dependency After 3,4-Methylenedioxymethamphetamine-Assisted Psychotherapy: A Prospective Long-Term Follow-Up Study," by Michael C. Mithoefer, Mark T. Wagner, Rick Doblin, et al. (Journal of Psychopharmacology, 2013).
  • "RETRACTED: Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ('Ecstasy')," by George A. Ricaurte, Jie Yuan, George Hatzidimitriou, Branden J. Cord, and Una D. McCann (Science, 2002).

EXTRAS:

  • "Why Aren’t All Drugs Legal? (Replay)," by People I (Mostly) Admire (2022).
  • "Can the Big Bad Wolf Save Your Life?" by Freakonomics Radio (2022).
  • "How Are Psychedelics and Other Party Drugs Changing Psychiatry?" by Freakonomics Radio (2020).

The episode 115. The Future of Therapy Is Psychedelic from the podcast People I (Mostly) Admire has a duration of 53:05. It was first published 30 Sep 03:00. The cover art and the content belong to their respective owners.

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131. Getting Old, Adventurously

Caroline Paul is a thrill-seeker and writer who is on a quest to encourage women to get outside and embrace adventure as they age. She and Steve talk about fighting fires, walking on airplane wings, and finding awe in birdwatching.

  • SOURCE:
    • Caroline Paul, author and former firefighter.
  • RESOURCES:
    • Tough Broad: From Boogie Boarding to Wing Walking ― How Outdoor Adventure Improves Our Lives as We Age, by Caroline Paul (2024).
    • "FAA Halts Sequim Wing-Walking Flights, Revokes Owner’s Pilot License," by Dominic Gates (The Seattle Times, 2024).
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    • The Gutsy Girl: Escapades for Your Life of Epic Adventure, by Caroline Paul (2016).
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    • Lost Cat: A True Story of Love, Desperation, and GPS Technology, by Caroline Paul (2013).
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    • "Arnold Schwarzenegger Has Some Advice for You," by People I (Mostly) Admire (2024).
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UPDATE: What It’s Like to Be Steve Levitt’s Daughters

Steve shows a different side of himself in very personal interviews with his two oldest daughters. Amanda talks about growing up with social anxiety and her decision not to go to college, while Lily speaks candidly about her battle with anorexia and the conversation she had with Steve that led her to seek treatment.

  • SOURCES:
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    • Amanda Levitt, daughter of Steve Levitt.
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130. Is Our Concept of Freedom All Wrong?

The economist Joseph Stiglitz has devoted his life to exposing the limits of markets. He tells Steve about winning an argument with fellow Nobel laureate Milton Friedman, why small governments don’t lead to more freedom, and why he’s not afraid to be an advocate.

  • SOURCE:
    • Joseph Stiglitz, professor at Columbia University and chief economist at the Roosevelt Institute.
  • RESOURCES:
    • The Road to Freedom: Economics and the Good Society, by Joseph Stiglitz (2024).
    • "Equilibrium in Competitive Insurance Markets: An Essay on the Economics of Imperfect Information," by Michael Rothschild and Joseph Stiglitz (The Quarterly Journal of Economics, 2010).
    • "Hirsh: The Missing Link on Obama's Economic Team," by Michael Hirsh (Newsweek, 2008).
    • Globalization and Its Discontents, by Joseph Stiglitz (2002).
    • Two Lucky People: Memoirs, by Milton Friedman and Rose Friedman (1998).
    • "On Value Maximization and Alternative Objectives of the Firm," by Sanford Grossman and Joseph Stiglitz (The Journal of Finance, 1977).
  • EXTRAS:
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  • SOURCE:
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  • RESOURCES:
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  • SOURCES:
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  • RESOURCES:
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  • EXTRAS:
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