Science Magazine Podcast cover logo

Hope in the fight against deadly prion diseases, and side effects of organic agriculture

35m · Science Magazine Podcast · 21 Mar 18:00

New clinical trials for treatments of an always fatal brain disease, and what happens with pests when a conventional and organic farm are neighbors First up on this week’s show, a new treatment to stave off prion disease goes into clinical trials. Prions are misfolded proteins that clump together and chew holes in the brain. The misfolding can be switched on in a number of ways—including infection with a misfolded prion protein from an animal or person. Staff Writer Meredith Wadman talks with host Sarah Crespi about new potential treatments—from antisense nucleotides to small molecules that interfere with protein production—for these fatal neurodegenerative diseases. Next on the show: Freelance producer Katherine Irving talks with Ashley Larsen, associate professor of agricultural and landscape ecology at the University of California, Santa Barbara, about the effects of organic farms on their neighbors. If there are lots of organic growers together, pesticide use goes down but conventional farms tend to use more pesticides when side by side with organic farms. This week’s episode was produced with help from Podigy. About the Science Podcast Authors: Sarah Crespi; Katherine Irving; Meredith Wadman LINKS FOR MP3 META Episode page: https://www.science.org/doi/10.1126/science.z91m76v Learn more about your ad choices. Visit megaphone.fm/adchoices

The episode Hope in the fight against deadly prion diseases, and side effects of organic agriculture from the podcast Science Magazine Podcast has a duration of 35:49. It was first published 21 Mar 18:00. The cover art and the content belong to their respective owners.

More episodes from Science Magazine Podcast

Restoring sight to blind kids, making babies without a womb, and challenging the benefits of clinical trials

Studying color vision in with children who gain sight later in life, joining a cancer trial doesn’t improve survival odds, and the first in our books series this year First on this week’s show, Staff Writer Jennifer Couzin-Frankel joins host Sarah Crespi to discuss the pros and cons of participating in clinical trials. Her story challenges the common thinking that participating in a trial is beneficial—even in the placebo group—for cancer patients. Next, Lukas Vogelsang, a postdoctoral fellow in the department of brain and cognitive sciences at the Massachusetts Institute of Technology, talks about research into color vision with “late-sighted” kids. Studying children who were born blind and then later gained vision gave researchers new insights into how vision develops in babies and may even help train computers to see better. Last up on the show is the first in our series of books podcasts on a future to look forward to. Books host Angela Saini talks with author Claire Horn, a researcher based at Dalhousie University’s Health Justice Institute. They discuss the implications of growing babies from fertilized egg to newborn infant—completely outside the body—and Horn’s book Eve: The Disobedient Future of Birth. This week’s episode was produced with help from Podigy. About the Science Podcast Authors: Sarah Crespi; Angela Saini; Jennifer Couzin-Frankel Episode page: https://www.science.org/doi/10.1126/science.z6gdgb4 Learn more about your ad choices. Visit megaphone.fm/adchoices

Stepping on snakes for science, and crows that count out loud

A roundup of online news stories featuring animals, and researchers get crows to “count” to four This week’s show is all animals all the time. First, Online News Editor Dave Grimm joins host Sarah Crespi to discuss stepping on venomous snakes for science, hunting ice age cave bears, and demolishing lizardlike buildings. Next, producer Kevin McLean talks with Diana Liao, a postdoctoral researcher at the University of Tübingen, about teaching crows to count out loud. They discuss the complexity of this behavior and how, like the famous band, these counting corvids have all the right vocal skills to do it. This week’s episode was produced with help from Podigy. About the Science Podcast Authors: Sarah Crespi; Kevin McLean; David Grimm Episode page: https://www.science.org/doi/10.1126/science.ztje4j6 Learn more about your ad choices. Visit megaphone.fm/adchoices

How the immune system can cause psychosis, and tool use in otters

On this week’s show: What happens when the body’s own immune system attacks the brain, and how otters’ use of tools expands their diet First on the show this week, when rogue antibodies attack the brain, patients can show bizarre symptoms—from extreme thirst, to sleep deprivation, to outright psychosis. Contributing Correspondent Richard Stone joins host Sarah Crespi to discuss the hunt for biomarkers and treatments for this cluster of autoimmune disorders that were once mistaken for schizophrenia or even demonic possession. Next on this episode, producer Katherine Irving talks with Chris Law, an evolutionary biologist at the University of Washington and the University of Texas at Austin, about how sea otters gain energy benefits (and dental benefits) when they use tools to tackle tougher prey such as snails or large clams. This week’s episode was produced with help from Podigy. About the Science Podcast Authors: Sarah Crespi; Richard Stone; Katherine Irving Episode page: https://www.science.org/doi/10.1126/science.z4pdg62 Learn more about your ad choices. Visit megaphone.fm/adchoices

A very volcanic moon, and better protections for human study subjects

Jupiter’s moon Io has likely been volcanically active since the start of the Solar System, and a proposal to safeguard healthy human subjects in clinical trials First on the show this week, a look at proposed protections for healthy human subjects, particularly in phase 1 clinical trials. Deputy News Editor Martin Enserink joins host Sarah Crespi to discuss the risks healthy participants face when involved in early testing of drugs for safety and tolerance. Then, we hear about a project to establish a set of global standards initiated by the Ethics Committee of France’s national biomedical research agency, INSERM. Next on this episode, a peek at the history of the most volcanically active body in the Solar System, Jupiter’s moon Io. Because the surface of Io is constantly being remodeled by its many volcanoes, it’s difficult to study its past by looking at craters or other landmarks. Katherine de Kleer, assistant professor of planetary science and astronomy at the California Institute of Technology, talks about using isotopic ratios in the moon’s atmosphere to estimate how long it’s been spewing matter into space. This week’s episode was produced with help from Podigy. About the Science Podcast Authors: Sarah Crespi; Martin Enserink Episode page: https://www.science.org/doi/10.1126/science.zyq2ig8 Learn more about your ad choices. Visit megaphone.fm/adchoices

Improving earthquake risk maps, and the world’s oldest ice

Bringing historical seismic reports and modern seismic risk maps into alignment, and a roundup of stories from our newsletter, ScienceAdviser First on the show this week, a roundup of stories with our newsletter editor, Christie Wilcox. Wilcox talks with host Sarah Crespi about the oldest ice ever found, how well conservation efforts seem to be working, and repelling mosquitoes with our skin microbes. Next on this episode, evaluating seismic hazard maps. In a Science Advances paper this week, Leah Salditch, a geoscience peril adviser at risk and reinsurance company Guy Carpenter, compared modern seismic risk map predictions with descriptions of past quakes. The analysis found a mismatch: Reported shaking in the past tended to be stronger than modern models would have predicted. She talks with Crespi about where this bias comes from and how to fix it. This week’s episode was produced with help from Podigy. About the Science Podcast Authors: Sarah Crespi; Christie Wilcox Episode page: https://www.science.org/doi/10.1126/science.zfj31xo Learn more about your ad choices. Visit megaphone.fm/adchoices

Every Podcast » Science Magazine Podcast » Hope in the fight against deadly prion diseases, and side effects of organic agriculture