CCO Neuroscience Podcast
by Clinical Care OptionsUpdates on new data and best practices in patient care across a wide variety of psychiatric and neurological illnesses from Clinical Care Options. Gain a deeper understanding and practical clinical insights on topics ranging from bipolar depression to Parkinson’s disease psychosis. Select episodes available for CME/CE credit.
Copyright: 2021 CCO Neuroscience Podcast
Episodes
Assess the Efficacy and Safety of Emerging Strategies That Impact Brain Cholesterol Turnover
23m · PublishedIn this episode, Drs. Halford and Hahndiscuss the current treatment landscape of developmental and epileptic encephalopathies (DEEs), such as Lennox-Gastaut syndrome and Dravet syndrome, and the emerging role of brain cholesterol in addressing seizure frequency. The full episode covers:
- How to diagnose these epilepsies and the FDA-approved treatment options in the first-line and second-line settings
- The role of antiseizure medications in DEE treatment management
- The nonpharmacological treatment options available to patients with DEEs
- The emerging role of brain cholesterol in neurologic diseases like DEEs and Alzheimer’s disease
- Results from the ELEKTRA clinical trial, including cholesterol synthase inhibitors’ impact on seizure frequency
- The future of soticlestat as a treatment option for pediatric patients with DEEs
Presenters:
Jonathan J. Halford, MD
Professor
Director, Translational Research Unit
Department of Neurology
Medical University of South Carolina
Charleston, SC
Cecil Hahn, MD, MPH, FRCPC
Professor
Pediatric Epileptologist
University of Toronto
Toronto, Ontario, Canada
Content based on an online CME program supported by an independent educational grant from Takeda Pharmaceuticals U.S.A., Inc.
Link to full program:
https://bit.ly/45UUpQy
Brain Cholesterol: The New Landscape of Neurological Disease Management
29m · PublishedIn this episode, Drs. Halford and White discussthe emerging role of brain cholesterol in the development and potential treatment of neurological diseases like epilepsy or Alzheimer and Huntington diseases. The full episode covers:
- Overview of brain cholesterol and its function in the body
- Pathogenesis potential for certain diseases via brain cholesterol
- Emerging research on a cholesterol synthase inhibitor as a novel therapy
- The future of soticlestat as a potential treatment option for pediatric epilepsies—Lennox-Gastaut syndrome and Dravet syndrome—and other neurological diseases
Presenters:
Jonathan J. Halford, MD
Professor
Director, Translational Research Unit
Department of Neurology
Medical University of South Carolina
Charleston, SC
H. Steve White, PhD
Professor, Department of Pharmacy
Co-Director, Center for Epilepsy Drug Discovery
School of Pharmacy
University of Washington
Seattle, Washington
Defining Alzheimer’s Disease and MCI Management in the Modern Era
24m · PublishedIn this episode, Drs. Sabbagh and Isaacson discuss how to best approach Alzheimer’s disease (AD) and mild cognitive impairment (MCI) in clinical practice, including accurately diagnosing patients and optimizing treatment in terms of patient preferences and reimbursement options.The full episode covers:
- Defining AD and MCI and their clinical presentation
- How to diagnose AD vs MCI
- Reimbursement landscape for current diagnosing and monitoring tools
- Precision medicine’s evolving role in diagnosing and treating patients with AD and/or MCI
Presenters:
Marwan Sabbagh, MD
Professor of Neurology
Alzheimer’s and Memory Disorders Division
Department of Neurology
Barrow Neurological Institute
Phoenix, Arizona
Richard Isaacson MD
Director of the Institute for Neurodegenerative Diseases
Florida
Keeping Up With the Treatment Landscape for MDD
28m · PublishedThe treatment landscape of major depression is increasingly shifting from monoaminergic agents to agents that modulate glutamate and GABA. Healthcare professionals need to stay up to date and educated on these changes in order to discuss the most current treatment options with their patients. In this podcast episode, we interview Dr Anita Clayton, a clinician researcher who has been involved in some of the clinical trials for these novel glutamatergic and GABAergic medications, and ask her key questions about mechanism of action and clinical application. Listeners will come away from this podcast episode more informed and more excited for the future of major depression care.
Presenters:
Anita Clayton, MD
David C. Wilson Professor and Chair
Department of Psychiatry and Neurobehavioral Sciences
Professor of Clinical Obstetrics and Gynecology
University of Virginia School of Medicine
Charlottesville, Virginia
This podcast episode is supported by an educational grant from Sage Therapeutics, Inc. and Biogen.
Link to full program:
https://bit.ly/3YdPMPa
Rett Syndrome Tomorrow: Management Options on the Horizon
22m · PublishedRett syndrome is a rare but severe neurodevelopmental disorder, and current treatment approaches primarily focus on symptom management and supportive care. However, recent clinical developments are providing hope for a changing treatment landscape. In this podcast episode, experts in Rett syndrome David N. Lieberman, MD, PhD, and Jeffrey Neul, MD, PhD, discuss trofinetide and blarcamesine, 2 agents in late-stage clinical trials as treatment options for Rett syndrome. Throughout their conversation, Drs Lieberman and Neul review the pivotal LAVENDER, DAFFODIL, AVATAR, and EXCELLENCE trials, including information on the safety and efficacy profiles of trofinetide and blarcamesine. The experts end their discussion with a conversation about the potential roles of ketamine and gene therapy in the management of Rett syndrome.
Presenters:
David N. Lieberman, MD, PhD
Instructor
Department of Neurology
Harvard Medical School
Attending Physician
Child Neurology
Boston Children’s Hospital
Boston, Massachusetts
Jeffrey Neul, MD, PhD
Director
Pediatrics
Vanderbilt University Medical Center
Nashville, Tennessee
This activity is supported by educational funding provided by Acadia Pharmaceuticals Inc.
To claim CME/CE credit for this podcast, complete the posttest here:
bit.ly/3JR4qq5.
For additional activities in this program, visit
bit.ly/3JR4qq5
Rett Syndrome Tomorrow: Management Options on the Horizon
22m · PublishedRett syndrome is a rare but severe neurodevelopmental disorder, and current treatment approaches primarily focus on symptom management and supportive care. However, recent clinical developments are providing hope for a changing treatment landscape. In this podcast episode, experts in Rett syndrome David N. Lieberman, MD, PhD, and Jeffrey Neul, MD, PhD, discuss trofinetide and blarcamesine, 2 agents in late-stage clinical trials as treatment options for Rett syndrome. Throughout their conversation, Drs Lieberman and Neul review the pivotal LAVENDER, DAFFODIL, AVATAR, and EXCELLENCE trials, including information on the safety and efficacy profiles of trofinetide and blarcamesine. The experts end their discussion with a conversation about the potential roles of ketamine and gene therapy in the management of Rett syndrome.
Presenters:
David N. Lieberman, MD, PhD
Instructor
Department of Neurology
Harvard Medical School
Attending Physician
Child Neurology
Boston Children’s Hospital
Boston, Massachusetts
Jeffrey Neul, MD, PhD
Director
Pediatrics
Vanderbilt University Medical Center
Nashville, Tennessee
This activity is supported by educational funding provided by Acadia Pharmaceuticals Inc.
To claim CME/CE credit for this podcast, complete the posttest here:
bit.ly/3JR4qq5.
For additional activities in this program, visit
bit.ly/3JR4qq5
Rett Syndrome Today: Current Options for Symptom Management
32m · PublishedRett syndrome affects many organ systems, and each patient has individual symptoms and experiences—there is no “one-size-fits-all” treatment approach. In this podcast episode, Rett syndrome experts David N. Lieberman, MD, PhD, and Shannon Standridge, DO, MPH, discuss some of the more common manifestations of Rett syndrome and current management strategies. While covering manifestations such as epilepsy, behavioral issues, and gastrointestinal distress, they highlight the value of a team approach to help the patient thrive. Throughout their conversation, Drs Lieberman and Standridge weave in real-world examples of interactions they have had with families of patients with Rett syndrome and offer insights on communication strategies for different aspects of management.
Presenters:
David N. Lieberman MD, PhD
Instructor
Department of Neurology
Harvard Medical School
Attending Physician
Child Neurology
Boston Children’s Hospital
Boston, Massachusetts
Shannon Standridge, DO, MPH
Professor
Division of Neurology
Vinaya Rett Syndrome and Related Spectrum Disorders Clinic
Cincinnati Children’s Hospital Medical Center
Cincinnati, Ohio
This activity is supported by educational funding provided by Acadia Pharmaceuticals Inc.
To claim CME/CE credit for this podcast, complete the posttest here:
http://bit.ly/41CeaeP
For additional activities in this program, visit
http://bit.ly/3lXuzda
Long-term Solutions for Long-term Diseases: Using Long-Acting Injectable Antipsychotics in Practice
29m · PublishedIn this podcast episode, Leslie Citrome, MD, MPH, and Adam Lowy, MD, share a wealth of knowledge about long-acting injectable (LAI) antipsychotics. Their conversation begins with an overview of the pharmacokinetic profiles of LAI antipsychotics and how they differ from their oral counterparts, as well as injection intervals available with current formulations. The experts also discuss the clinical utility of LAI antipsychotics in psychiatry practice, highlighting their role in assuring medication adherence and their application in both first- and later-episode psychosis. Finally, Drs Citrome and Lowy hit on practical aspects of incorporating LAI antipsychotics into patient care: communicating with patients to dispel myths and stigma surrounding injectable medications, identifying injection resources in your medical community, and strategies to navigate insurance barriers.
Throughout the podcast, Drs Citrome and Lowy reference several links to outside sources that can provide valuable education on LAI antipsychotics. Those links are listed below for your convenience.
Administering LAI Into Dorsal Gluteal Site:
https://bit.ly/3XjSm5a
Administering LAI Into Deltoid Site:
https://bit.ly/3Xlyq1L
Administering LAI Into Abdominal Site:
https://bit.ly/3wgGJ2Z
Presenters:
Leslie Citrome, MD, MPH
Clinical Professor
Department of Psychiatry and Behavioral Sciences
New York Medical College
Valhalla, New York
Adam Lowy, MD
Staff Psychiatrist
Ellenhorn
Los Angeles, California
This activity is supported by educational funding provided byOtsuka America Pharmaceutical, Inc. and Lundbeck.
For additional activities in this program, visit:
https://bit.ly/3iM0HiP
Rett Syndrome Today and Tomorrow: What Is Rett Syndrome?
29m · PublishedIn this podcast episode, experts in Rett syndrome, David N. Lieberman, MD, PhD, and Jeffrey Neul, MD, PhD, provide a comprehensive overview of Rett syndrome (RTT), a rare but severe neurodevelopmental disorder. They begin with a discussion on the clinical characteristics and typical disease progression of RTT before diving into the various genetic markers and how they may, or may not, be used in the diagnosis and prognosis. Finally, the experts ponder the future of RTT diagnoses, touching upon how we might identify RTT and intervene earlier, potential utilization of biomarkers, and the role of measurement-based care.
Presenters:
David N. Lieberman MD, PhD
Instructor
Department of Neurology
Harvard Medical School
Attending Physician
Child Neurology
Boston Children's Hospital
Boston, Massachusetts
Jeffrey Neul MD, PhD
Director
Pediatrics
Vanderbilt University Medical Center
Nashville, Tennessee
This activity is supported by educational funding provided by Acadia Pharmaceuticals Inc.
To claim CME/CE credit for this podcast, complete the posttest here:
https://bit.ly/3WjtMjA
For additional activities in this program, visit:
https://bit.ly/3kfAn0U
To the Rescue: Incorporating Rescue Medications Into Epilepsy Treatment Plans
28m · PublishedIn this podcast episode, epileptologists Aatif Husain, MD, and John Stern, MD, have a conversation about rescue therapies and how they fit into the spectrum of epilepsy management. Their discussion begins with sharing what they consider the utility of rescue therapies to be in the overall spectrum of epilepsy. As the conversation goes on, they address the role of rescue therapies in more specific patient populations, such as the newly diagnosed patient, a patient experiencing seizure clusters, and patients who may be experiencing either very few or relatively many breakthrough seizure events. In all scenarios, the experts relate the use of rescue therapies as “insurance”—hoping that the agents don’t have to be used, but having them available as coverage in the worst-case scenario. The podcast goes on to discuss rescue therapies in terms of available routes and mechanisms of action and practical strategies for talking to patients about these agents. Rounding out the episode, Drs Husain and Stern express their hopes for future developments in epilepsy management.
Presenters:
Aatif Husain, MD
Professor
Division of Epilepsy, Sleep and Clinical Neurophysiology
Department of Neurology
Duke University Medical Center
Durham, North Carolina
John Stern, MD
Professor
Neurology
Geffen School of Medicine, UCLA
Director
Epilepsy Clinical Program
UCLA Department of Neurology
Los Angeles, California
This content is based on a CE/CME program supported by an independent educational grant from Neurelis, Inc.
For additional activities in this program, visit
https://bit.ly/3GiLlu4.
CCO Neuroscience Podcast has 33 episodes in total of non- explicit content. Total playtime is 14:46:57. The language of the podcast is English. This podcast has been added on November 25th 2022. It might contain more episodes than the ones shown here. It was last updated on May 16th, 2024 22:11.