Inside Health

Barely a day goes by without more headlines around new weight-loss drugs, from the issue of global shortages, to investigations into suicide risk, and debate over just how long people will need to be on them. But in this episode of Inside Health we’re going to look at something slightly different - and perhaps unexpected. James Gallagher meets lifelong dieter Cheri who has lost just over three stone on semaglutide but she’s also noticed other effects from her weekly injection; a calmer mind and a complete lack of desire for her much-loved vapes. She wants to know what’s going on – so we seek out some scientists to help us get to the bottom of it. From the evidence gathered so far, are there hints that these drugs could offer potential to treat serious addiction? And have you ever heard of “bed rotting”? It doesn’t sound particularly enticing - but James gives it a go in the name of science and we explain all in the programme with the help of two experts. What health questions do you want us to answer? Email the team at [email protected] Declared interests: Professor Giles Yeo: "I have a PhD student part-funded by Novo Nordisk. I consult for Novo Nordisk and Eli Lilly." Dr Tony Goldstone: "I have previously been a member of Data Safety Monitoring Board for clinical trials of Liraglutide for obesity by Novo Nordisk, and have received an honorarium as a conference speaker from Novo Nordisk." Presenter: James Gallagher Producer: Gerry Holt Editor: Erika Wright Production Coordinator: Jonathan Harris Studio Producer: Duncan Hannant (Photo: Cheri Ferguson with her Ozempic pen. Credit Cheri Ferguson)

One year after the peak of UK infections, can we determine what actions brought mpox cases down? A year ago, mpox – the virus formally known as monkeypox – was spreading in the UK. These infections largely impacted the gay, bisexual and men who have sex with men community, with news cases peaking at 350 per week. One of these individuals was Martin Joseph, who tells James Gallagher how a lack of accessible information and the stigma he observed during his illness inspired him to create a mpox-based podcast so others wouldn’t feel so alone. Thankfully, 2023 so far has told a different story for mpox. Infections in the UK have remained relatively low, and in May, the World Health Organisation declared the mpox global health emergency over. But what helped bring the UK outbreak under control? James is joined by Jake Dunning, infectious diseases doctor and researcher at the University of Oxford, and Claire Dewsnap, sexual health doctor and president of the British Association of Sexual Health and HIV (BASHH), to discuss potential factors, takeaways and whether we are really ‘done’ with mpox. How often should we go to the dentist? Listener Mary emailed [email protected] to query the time needed between check-ups. James hears the evidence from Janet Clarkson, professor of dentistry at the University of Dundee, who explains the unlikely origins of our bi-annual appointments! Presenter: James Gallagher Producer: Julia Ravey Editor: Erika Wright Production Co-ordinator: Jonathan Harris Studio Producer: Donald McDonald (Photo: Monkeypox Credit: Uma Shankar sharma | Getty Images)

Our guinea-pig presenter James Gallagher has been eating either extremely fast or excruciatingly slow to figure out what our eating speed does to our health. Dr Sarah Berry from Kings College London explains it’s not good news if you devour your dinner! And we get to the bottom of the headlines on cancer and the artificial sweetener aspartame. James and Prof David Spiegelhalter discuss why these cancer-scare stories keep on happening. Get in touch with the team (especially if you have any questions about headache or migraine) on [email protected] Presenter: James Gallagher Producer: Julia Ravey Editor: Erika Wright Production Co-ordinator: Jonathan Harris Studio Manager: Giles Aspen

After the hottest June in history and record-breaking temperatures last year, the UK is really feeling the heat. But, we’re not alone. Last week the world experienced the hottest day in history - and forecasters warn this is just a taste of what is to come. Here on Inside Health we love a tricky question - so in the first episode of the new series we’re chasing down the answer to a pretty timely one, how hot is too hot for our health. James heads into the lab to explore exactly what is going on inside our bodies when it gets hotter. He gets wired up and locked inside a heated chamber to find out what factors matter most, from core temperature to humidity, and learns which is more deadly, cold or heat. He also hears about a surprising tip to stay safe in the heat. Do join us on what promises to be a rather hot and sweaty journey… How hot is too hot for you? And what other health issues should we be covering? Do get in touch via email at [email protected] Presenter: James Gallagher Producer: Gerry Holt Editor: Erika Wright Production Coordinator: Jonathan Harris Technical Producer: Tim Heffer Image: James Gallagher in the lab. Credit: Dan Welsh

James Gallagher finds out if we've turned into a nation of grinders after reports from dentists of increased clenching and cracking of teeth. Margaret McCartney answers your feedback about the new weight-loss drug, exercise for your back, sperm counts and then goes for retail therapy with James to discover how useful shopping data could be for understanding our health.

James meets Ian who has Parkinson's disease and hears how ballet has helped with his symptoms, as a major new review of the evidence shows exercise really does make a difference. And microplastics which can be found in drinking water and food stuffs have now been identified in human vein tissue. James unpicks what this means for our health. Presenter: James Gallagher Producer: Erika Wright and Harry Lewis

James Gallagher asks whether a weight-loss drug on the NHS heralds a new era in tackling obesity? He meets Jan who lost nearly 4 stone after being part of a trial taking a weekly injection of Semaglutide for 15 months alongside advice on meals and exercise. However, when people stop taking the drug the weight starts to go back on. Add to that supply shortages with heightened private demand and some doctors think the drug is as controversial as they come. James unpicks the ethical and societal dilemmas against a backdrop of half the world's population projected to be overweight or obese by 2035. Producer: Erika Wright Declared interests Dr Margaret McCartney: "No conflicts to declare." Prof Sir Stephen O’Rahilly : "in the past has been a remunerated consultant and has had research collaboration with Novo Nordisk." Professor Naveed Sattar: "consulted for and/or received speaker honoraria from Novo Nordisk, Abbott Laboratories, Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Hanmi Pharmaceuticals, Merck Sharp & Dohme, Novartis, Pfizer, and Sanofi; and grant support paid to his university from AstraZeneca, Boehringer Ingelheim, Novartis, and Roche Diagnostics. He was a co-investigator in lifestyle trials such as DiRECT and co-lead for STANDby."

Lower back pain impacts millions of adults every year and, in many cases, diagnosis can be murky. Non-specific pain is personal and complex, driven by factors such as injury, sensitivity and perception. But are there methods to help manage back pain and live a happier life in the process? James Gallagher is joined at a yoga studio in Stockbridge, Hampshire by Emma Godfrey, psychology researcher at Kings College London, chiropractor David Elliot, physiotherapist Richard Husselbee, and yoga instructor, Alison Trewhela to answer all your back pain questions (and takes to the mat himself to try some gentle healthy lower back poses). Producer: Julia Ravey

James Gallagher investigates whether there is a decline in male sperm including the results of his own sperm count analysis. He meets a couple who conceived after having treatment for a varicocele, enlarged veins in the testes that can heat the sperm up and the leading known cause of male infertility. And James is joined by leading scientists in the field to debate whether sperm counts are falling. Producer: Erika Wright

Can magic mushrooms help your mental health? James Gallagher cuts through the hype and examines the evidence to find out if psychedelics can treat depression. Presenter: James Gallagher Producer: Geraldine Fitzgerald