Coronavirus (COVID-19) Q&A

Steven M. Bradley, MD, MPH joins JAMA Network editors to discuss a randomized clinical trial evaluating the safety and efficacy of 2 chloroquine diphosphate dosages in patients with severe coronavirus disease 2019 (COVID-19). Read the editorial here: https://ja.ma/2JC5sGx.

JNO Live is a weekly broadcast featuring conversations about the latest research being published in JAMA Network Open. Follow us on Facebook, Twitter and YouTube for details on the next broadcast.

A new exhibit on the 1918 flu pandemic asks: What is an individual's responsibility to their community during a pandemic? Exhibit curator Jane Boyd and museum manager Nancy Hill take Jennifer Abbasi on a tour of the medical museum's new exhibit just weeks before the COVID-19 outbreak first emerged.

Pandemic Part 1: 1918 Flu Pandemic and COVID-19

Read the article:

Twentieth-Century Lessons for a Modern Coronavirus Pandemic

Medical historian Howard Markel, MD, PhD, director of the University of Michigan's Center for the History of Medicine, speaks with JAMA Fishbein fellow Angel Desai, MD, about lessons from the devastating 1918 flu pandemic. Markel discusses his research into the effects of social distancing on US death rates during the worldwide outbreak.

Pandemic Part 2: A Trip to Philadelphia’s Mutter Museum

Read the article:

Twentieth-Century Lessons for a Modern Coronavirus Pandemic

Marc Lipsitch, DPhil, an infectious diseases epidemiologist developing biological and modeling approaches to pathogen transmission and outbreaks, discusses evolution of the COVID-19 pandemic in summer and fall 2020. Originally recorded April 22, 2020.

Management of COVID-19-related respiratory failure differs from what is necessary for ARDS. Rather than having alveolar edema, COVID-19 patients have pulmonary vascular dysregulation. Gas exchange is severely compromised with little reduction in lung compliance. Ventilatory support for COVID-19 patients requires higher than normal tidal volumes with minimal PEEP and allowance for higher than usual serum CO2 levels. How the unique pathophysiology of respiratory failure should be treated is discussed by John J. Marini, MD, professor of medicine at the University of Minnesota.

JAMA Health Forum editors John Ayanian, MD, MPP, and Melinda Buntin, PhD, discuss changes in US health care and health policy driven by the coronavirus pandemic. Recorded April 16, 2020.

Rochelle Walensky, MD, MPH, of Harvard University discusses public health strategies and policies for lifting shelter-in-place and quarantine and for returning the US to a new post-first-wave normal. Recorded Monday April 20, 2020.

New York City coronavirus update from Mitchell Katz, MD, President and CEO of NYC Health + Hospitals, the largest municipal public health system in the United States. Recorded April 13, 2020.

Questions about testing, chloroquine toxicity, duration of immunity and reinfection, and what to expect next are gripping the US as the novel coronavirus spreads. JAMA Associate Editor Preeti Malani, MD, professor of medicine and Chief Health Officer at the University of Michigan, discusses recent developments in a live conversation with JAMA Editor in Chief Howard Bauchner. Recorded on April 6, 2020.

NIAID Director and Presidential Coronavirus Task Force Advisor Anthony Fauci, MD, discusses recent developments in the global COVID-19 pandemic with JAMA Editor Howard Bauchner, MD. Recorded April 8, 2020.