Intention to Treat

This episode considers a new treatment for hypertrophic cardiomyopathy, the world’s most common inherited heart condition, which most affected people don’t even realize they have.

A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2400702.

This episode examines CAR T-cell therapy’s early successes, broader promise, and emerging risks, as the FDA considers reports of occasional secondary cancers.

A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2400701.

This episode explores the fastest-growing neurologic condition in the world, Parkinson’s disease. What have we learned in recent years, and where are the greatest hopes for the future?

A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2414003.

In this episode, parents who have lost children to gun accidents and physicians working for gun safety discuss the number-one killer of U.S. children and what doctors can do about it.

A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2314002.

This episode of “Intention to Treat” tells the story of the Freedom House Ambulance Service — a group of Black laypeople in Pittsburgh who underwent intensive training to become the first paramedics in the United States. [Originally aired on May 4, 2023.]

A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2303614.

Highlighting gaps in communication near the end of life, this podcast episode explores a new approach to preparing patients with serious illness and their families for all possible outcomes.

A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2314001.

In the second half of our podcast series on historical injustices, guests Evelynn Hammonds and David Jones examine the racism of post-World War II American medicine and its lessons for the present day.

A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2314000.

Over its 200-plus years, the Journal has sometimes published articles that have perpetuated injustices against various groups of people. A new Perspective series explores that history and its lessons.

A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2311329.

This episode examines Covid-19 variants that are currently circulating, recommendations for booster shots, and new treatments in the pipeline.

A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2311327.

This episode examines the need for and promise of xenotransplantation, considering first the plight of patients and then the progress being made by researchers.

A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2309946.